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Genetic Test Determines Aggressiveness of Neuroblastomas: Neuroblastoma is among the types of cancer that particularly often affect children. Between one and three girls and boys in 100,000 are diagnosed with this growth of the nervous system before age 14. Scientists of the National Genome Research Network (NGFN, www.ngfn.de) have developed a method, based on the gene activity of tumor cells, for assessing the aggressiveness of neuroblastomas right at the time of diagnosis.
Disturbed circadian rhythm reinforces tendency to alcoholism: People whose internal clock is out of phase would appear to have a greater attraction to alcohol, according to the research findings of the German National Genome Research Network ( NGFN ). A group of scientists led by Professor Rainer Spanagel at the Central Institute of Mental Health, University of Heidelberg, have observed that mice with a specific mutation in the per2 gene demonstrate a particular affinity to alcohol.
Hope springs from the tea plantation relief for Huntingtons patients: It has been known for some time that green tea has a beneficial effect on health. Scientists working for the German National Genome Research Network (NGFN) have now discovered that it might even provide relief to patients suffering from Huntingtons chorea. The compound epigallocatechin-3-gallate (EGCG), which can be extracted from green tea, slows down aggregation (clump formation) of the protein huntingtin. The research group led by Professor Wanker of the Max Delbrück Center for Molecular Medicine (MDC) recently presented its findings at an international conference on diseases of the nervous system in Berlin.
Alzheimers protein has important function in the healthy nervous system: Important new findings on possible side-effects of Alzheimers treatment: blocking of the protein BACE 1 with appropriate drugs may be able to prevent the development of Alzheimers plaques in the brain, but may also stop the formation of an important insulating layer around the nerve fibres
27 genes offer a molecular diagnosis of heart failure: Scientists working with the National Genome Research Network (NGFN) have now succeeded, for the first time ever, in pinpointing which genes in particular are involved in the late stages of a specific cardiac muscle weakness known as dilatative cardiomyopathy. These genetic blueprints offer tremendous potential for the improved diagnosis and treatment of this complex condition.
Genetic variations increase risk of type II diabetes and affect body weight: An international team of researchers has identified a genetic variation that increases the risk of type II diabetes mellitus. Type II diabetes is a disease affecting the metabolism of sugar. The body is initially able to generate enough of the hormone insulin, but it is unable to work properly on the target cells. The consequence is that the cells do not open up to take sugar out of the bloodstream. The blood is over-sugared. As the disease progresses, the pancreas produces less and less insulin so that the status of the condition deteriorates further. Previously, this form of diabetes was also known as age-related diabetes. Nowadays, however, more and more younger patients are suffering from this metabolic disorder, which is not least due to the fact that more and more young people are overweight or even obese.
NGFN Research Team Discovers First Susceptibility Gene for Crohn's Disease: Mutations of the NOD2 gene cause a truncation of the NOD2 protein. This leads to an altered response to bacteria. The frequent consequence: Morbus Crohn.
On the Track to Understanding the Molecular Causes of the Down Syndrome: People with this syndrome have 3 instead of 2 "chromosomes 21" in their cells. Activities of genes of chromosome 21 have been catalogued in a "gene expression atlas" that will be a tool for investigating the genetic causes of "Down Syndrome".
The German Mouse Clinic: In this facility, which is unique throughout the world, mice with genetic alterations are screened in order to find out if these alterations lead to heritable diseases.

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	en Up one level Genetic Test Determines Aggressiveness of Neuroblastomas Neuroblastoma is among the types of cancer that particularly often affect children. Between one and three girls and boys in 100,000 are diagnosed with this growth of the nervous system before age 14. Scientists of the National Genome Research Network (NGFN, www.ngfn.de) have developed a method, based on the gene activity of tumor cells, for assessing the aggressiveness of neuroblastomas right at the time of diagnosis. Disturbed circadian rhythm reinforces tendency to alcoholism People whose internal clock is out of phase would appear to have a greater attraction to alcohol, according to the research findings of the German National Genome Research Network ( NGFN ). A group of scientists led by Professor Rainer Spanagel at the Central Institute of Mental Health, University of Heidelberg, have observed that mice with a specific mutation in the per2 gene demonstrate a particular affinity to alcohol. Hope springs from the tea plantation relief for Huntingtons patients It has been known for some time that green tea has a beneficial effect on health. Scientists working for the German National Genome Research Network (NGFN) have now discovered that it might even provide relief to patients suffering from Huntingtons chorea. The compound epigallocatechin-3-gallate (EGCG), which can be extracted from green tea, slows down aggregation (clump formation) of the protein huntingtin. The research group led by Professor Wanker of the Max Delbrück Center for Molecular Medicine (MDC) recently presented its findings at an international conference on diseases of the nervous system in Berlin. Alzheimers protein has important function in the healthy nervous system Important new findings on possible side-effects of Alzheimers treatment: blocking of the protein BACE 1 with appropriate drugs may be able to prevent the development of Alzheimers plaques in the brain, but may also stop the formation of an important insulating layer around the nerve fibres 27 genes offer a molecular diagnosis of heart failure Scientists working with the National Genome Research Network (NGFN) have now succeeded, for the first time ever, in pinpointing which genes in particular are involved in the late stages of a specific cardiac muscle weakness known as dilatative cardiomyopathy. These genetic blueprints offer tremendous potential for the improved diagnosis and treatment of this complex condition. Genetic variations increase risk of type II diabetes and affect body weight An international team of researchers has identified a genetic variation that increases the risk of type II diabetes mellitus. Type II diabetes is a disease affecting the metabolism of sugar. The body is initially able to generate enough of the hormone insulin, but it is unable to work properly on the target cells. The consequence is that the cells do not open up to take sugar out of the bloodstream. The blood is over-sugared. As the disease progresses, the pancreas produces less and less insulin so that the status of the condition deteriorates further. Previously, this form of diabetes was also known as age-related diabetes. Nowadays, however, more and more younger patients are suffering from this metabolic disorder, which is not least due to the fact that more and more young people are overweight or even obese. NGFN Research Team Discovers First Susceptibility Gene for Crohn's Disease Mutations of the NOD2 gene cause a truncation of the NOD2 protein. This leads to an altered response to bacteria. The frequent consequence: Morbus Crohn. On the Track to Understanding the Molecular Causes of the Down Syndrome People with this syndrome have 3 instead of 2 "chromosomes 21" in their cells. Activities of genes of chromosome 21 have been catalogued in a "gene expression atlas" that will be a tool for investigating the genetic causes of "Down Syndrome". The German Mouse Clinic In this facility, which is unique throughout the world, mice with genetic alterations are screened in order to find out if these alterations lead to heritable diseases.	Print page Back